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Estradiol, also extracted from oestradiol, is a steroid, estrogen and primary female sex hormone. It is named and plays an important role in regulating women's and eternal reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues such as breasts, uterus and vagina during puberty, adulthood and pregnancy, but it also has important effects in many other tissues , Including bone, fat, skin, liver and brain. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well.
Estradiol is produced in particular in the follicles of the female ovaries, but also in other endocrine (ie hormonal) and non-endocrine tissues (eg, fatty, hepatic, adrenal, mammary and neurological tissues) . Estradiol is biosynthesized from cholesterol through a series of chemical intermediates. One main pathway involves the generation of 4-androstenedione, which is converted to estrone by aromatase followed by 17β-hydroxysteroid dehydrogenase in estradiol. Alternatively, 4-androstenedione can be converted into testosterone, an androgen and primary male sex hormone, which in turn can be flavored in estradiol.
This drug is a female hormone. It is used by women to help reduce the symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the creation of less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly into the vagina should be considered prior to oral, absorbed or injected medications.
Some estrogen products can also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other drugs (such as raloxifene, bisphosphonates, including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered prior to estrogen administration.
Some men and women may also use certain estrogen products to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not Able to produce enough estrogen (eg due to hypogonadism, failure of the primary ovary).
Your dose of estradiol will depend on the condition that is being treated.
Estradiol tablets in doses of 0.5 milligrams (mg), 1 mg, or 2 mg are typically given on a daily basis.
They can also be prescribed to be taken for three weeks, followed by one week of no medication.
The tablets can be taken more than once a day for some conditions.
The topical gel or emulsions are applied to the skin at the same time each day.
The vaginal ring is inserted in the vagina and left for three months at a time.
The patch should be applied to a dry, clean, hairless part of the trunk (but not the breasts). It should not be placed on irritated or damaged skin.
You should rotate the site of application, with at least one week between repeated applications to any one site.
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